jak stat Search Results


endogenous metabolite compound library  (TargetMol)
95
TargetMol endogenous metabolite compound library
Fig. 1. Normalized TMPRSS2-HiBiT signal under treatment of compounds from (A) diversified building block library, (B) bioactive compound library, or (C) human <t>endogenous</t> <t>metabolite</t> library, at concentration of 10 μM and adjusted to corresponding ATP-Glo signal.
Endogenous Metabolite Compound Library, supplied by TargetMol, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/jak+stat/JAK-STAT+Compound+Library/pm39156721-57-9-15
Average 95 stars, based on 1 article reviews
endogenous metabolite compound library - by Bioz Stars, 2026-11
95/100 stars
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primerarray jak stat signaling pathway human qpcr array  (TaKaRa)
93
TaKaRa primerarray jak stat signaling pathway human qpcr array
Figure 2. TYK2 inhibition leads to compensatory stimulation of the MAPK pathway in MPNST cells. A, JH-2–002 cells were treated with 40 mmol/L WU-12 or control for 48 hours, and gene expression was analyzed by <t>qPCR</t> array for JAK/STAT pathway–related genes. Log2 fold changes of significantly changed genes are graphed. B, JW23.3 cellswere treated with control or 40 mmol/LWU-12 or WU-76 for 48 hours. Global gene expressionwas determined byRNA-seq pathway analysis. Changes in gene expression for WU-12 versus control were examined by RNA-seq for genes downstream of STAT3 in a heatmap (C) and boxplot (D), as well as MEK/MAPK pathway genes in a volcano plot (E), enrichment plot (F), and boxplot (G). P < 0.05 vs. vehicle control.
Primerarray Jak Stat Signaling Pathway Human Qpcr Array, supplied by TaKaRa, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 93 stars, based on 1 article reviews
primerarray jak stat signaling pathway human qpcr array - by Bioz Stars, 2026-11
93/100 stars
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auclast  (Cell Signaling Technology Inc)
91
Cell Signaling Technology Inc auclast
Figure 2. TYK2 inhibition leads to compensatory stimulation of the MAPK pathway in MPNST cells. A, JH-2–002 cells were treated with 40 mmol/L WU-12 or control for 48 hours, and gene expression was analyzed by <t>qPCR</t> array for JAK/STAT pathway–related genes. Log2 fold changes of significantly changed genes are graphed. B, JW23.3 cellswere treated with control or 40 mmol/LWU-12 or WU-76 for 48 hours. Global gene expressionwas determined byRNA-seq pathway analysis. Changes in gene expression for WU-12 versus control were examined by RNA-seq for genes downstream of STAT3 in a heatmap (C) and boxplot (D), as well as MEK/MAPK pathway genes in a volcano plot (E), enrichment plot (F), and boxplot (G). P < 0.05 vs. vehicle control.
Auclast, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 91/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/jak+stat/Jak%2FStat+Pathway+Inhibitors+Antibody+Sampler+Kit/pm40898858-56-5-6
Average 91 stars, based on 1 article reviews
auclast - by Bioz Stars, 2026-11
91/100 stars
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chemical compound libraries  (Selleck Chemicals)
92
Selleck Chemicals chemical compound libraries
Figure 2. TYK2 inhibition leads to compensatory stimulation of the MAPK pathway in MPNST cells. A, JH-2–002 cells were treated with 40 mmol/L WU-12 or control for 48 hours, and gene expression was analyzed by <t>qPCR</t> array for JAK/STAT pathway–related genes. Log2 fold changes of significantly changed genes are graphed. B, JW23.3 cellswere treated with control or 40 mmol/LWU-12 or WU-76 for 48 hours. Global gene expressionwas determined byRNA-seq pathway analysis. Changes in gene expression for WU-12 versus control were examined by RNA-seq for genes downstream of STAT3 in a heatmap (C) and boxplot (D), as well as MEK/MAPK pathway genes in a volcano plot (E), enrichment plot (F), and boxplot (G). P < 0.05 vs. vehicle control.
Chemical Compound Libraries, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/jak+stat/JAK%2FSTAT+compound+library/pmc11335859-166-4-27
Average 92 stars, based on 1 article reviews
chemical compound libraries - by Bioz Stars, 2026-11
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raybiotech aah jakstat 1 phosphorylation array  (RayBiotech inc)
94
RayBiotech inc raybiotech aah jakstat 1 phosphorylation array
Figure 2. TYK2 inhibition leads to compensatory stimulation of the MAPK pathway in MPNST cells. A, JH-2–002 cells were treated with 40 mmol/L WU-12 or control for 48 hours, and gene expression was analyzed by <t>qPCR</t> array for JAK/STAT pathway–related genes. Log2 fold changes of significantly changed genes are graphed. B, JW23.3 cellswere treated with control or 40 mmol/LWU-12 or WU-76 for 48 hours. Global gene expressionwas determined byRNA-seq pathway analysis. Changes in gene expression for WU-12 versus control were examined by RNA-seq for genes downstream of STAT3 in a heatmap (C) and boxplot (D), as well as MEK/MAPK pathway genes in a volcano plot (E), enrichment plot (F), and boxplot (G). P < 0.05 vs. vehicle control.
Raybiotech Aah Jakstat 1 Phosphorylation Array, supplied by RayBiotech inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/jak+stat/Human+JAK%2FSTAT+Pathway+Phosphorylation+Array+C1/bio_rxiv__64898__2026__08__18__745521-361-6-6
Average 94 stars, based on 1 article reviews
raybiotech aah jakstat 1 phosphorylation array - by Bioz Stars, 2026-11
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anti socs1  (Boster Bio)
93
Boster Bio anti socs1
Figure 2. TYK2 inhibition leads to compensatory stimulation of the MAPK pathway in MPNST cells. A, JH-2–002 cells were treated with 40 mmol/L WU-12 or control for 48 hours, and gene expression was analyzed by <t>qPCR</t> array for JAK/STAT pathway–related genes. Log2 fold changes of significantly changed genes are graphed. B, JW23.3 cellswere treated with control or 40 mmol/LWU-12 or WU-76 for 48 hours. Global gene expressionwas determined byRNA-seq pathway analysis. Changes in gene expression for WU-12 versus control were examined by RNA-seq for genes downstream of STAT3 in a heatmap (C) and boxplot (D), as well as MEK/MAPK pathway genes in a volcano plot (E), enrichment plot (F), and boxplot (G). P < 0.05 vs. vehicle control.
Anti Socs1, supplied by Boster Bio, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/jak+stat/Anti-SOCS1+Antibody+Picoband/pmc12896625-44-0-6
Average 93 stars, based on 1 article reviews
anti socs1 - by Bioz Stars, 2026-11
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phosphorylation  (RayBiotech inc)
94
RayBiotech inc phosphorylation
Figure 2. TYK2 inhibition leads to compensatory stimulation of the MAPK pathway in MPNST cells. A, JH-2–002 cells were treated with 40 mmol/L WU-12 or control for 48 hours, and gene expression was analyzed by <t>qPCR</t> array for JAK/STAT pathway–related genes. Log2 fold changes of significantly changed genes are graphed. B, JW23.3 cellswere treated with control or 40 mmol/LWU-12 or WU-76 for 48 hours. Global gene expressionwas determined byRNA-seq pathway analysis. Changes in gene expression for WU-12 versus control were examined by RNA-seq for genes downstream of STAT3 in a heatmap (C) and boxplot (D), as well as MEK/MAPK pathway genes in a volcano plot (E), enrichment plot (F), and boxplot (G). P < 0.05 vs. vehicle control.
Phosphorylation, supplied by RayBiotech inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/jak+stat/Human+JAK%2FSTAT+Pathway+Phosphorylation+Array+C1/pm42858253-989-0-9
Average 94 stars, based on 1 article reviews
phosphorylation - by Bioz Stars, 2026-11
94/100 stars
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jak  (Eli Lilly)
86
Eli Lilly jak
Figure 2. TYK2 inhibition leads to compensatory stimulation of the MAPK pathway in MPNST cells. A, JH-2–002 cells were treated with 40 mmol/L WU-12 or control for 48 hours, and gene expression was analyzed by <t>qPCR</t> array for JAK/STAT pathway–related genes. Log2 fold changes of significantly changed genes are graphed. B, JW23.3 cellswere treated with control or 40 mmol/LWU-12 or WU-76 for 48 hours. Global gene expressionwas determined byRNA-seq pathway analysis. Changes in gene expression for WU-12 versus control were examined by RNA-seq for genes downstream of STAT3 in a heatmap (C) and boxplot (D), as well as MEK/MAPK pathway genes in a volcano plot (E), enrichment plot (F), and boxplot (G). P < 0.05 vs. vehicle control.
Jak, supplied by Eli Lilly, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/jak+stat/jak+stat/pm41444262-363-17-23
Average 86 stars, based on 1 article reviews
jak - by Bioz Stars, 2026-11
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mouse jak/ stat signaling pathway genearray  (SuperArray Bioscience Corporation)
90
SuperArray Bioscience Corporation mouse jak/ stat signaling pathway genearray
Figure 2. TYK2 inhibition leads to compensatory stimulation of the MAPK pathway in MPNST cells. A, JH-2–002 cells were treated with 40 mmol/L WU-12 or control for 48 hours, and gene expression was analyzed by <t>qPCR</t> array for JAK/STAT pathway–related genes. Log2 fold changes of significantly changed genes are graphed. B, JW23.3 cellswere treated with control or 40 mmol/LWU-12 or WU-76 for 48 hours. Global gene expressionwas determined byRNA-seq pathway analysis. Changes in gene expression for WU-12 versus control were examined by RNA-seq for genes downstream of STAT3 in a heatmap (C) and boxplot (D), as well as MEK/MAPK pathway genes in a volcano plot (E), enrichment plot (F), and boxplot (G). P < 0.05 vs. vehicle control.
Mouse Jak/ Stat Signaling Pathway Genearray, supplied by SuperArray Bioscience Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/jak+stat/mouse+jak++stat+signaling+pathway+genearray/10__3892_slash_ijmm_00000105-64-1-13
Average 90 stars, based on 1 article reviews
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metacore pathway map for development leptin signaling via jak/stat and mitogen-activated protein kinase (mapk) cascades  (GeneGo Inc)
90
GeneGo Inc metacore pathway map for development leptin signaling via jak/stat and mitogen-activated protein kinase (mapk) cascades
Figure 2. TYK2 inhibition leads to compensatory stimulation of the MAPK pathway in MPNST cells. A, JH-2–002 cells were treated with 40 mmol/L WU-12 or control for 48 hours, and gene expression was analyzed by <t>qPCR</t> array for JAK/STAT pathway–related genes. Log2 fold changes of significantly changed genes are graphed. B, JW23.3 cellswere treated with control or 40 mmol/LWU-12 or WU-76 for 48 hours. Global gene expressionwas determined byRNA-seq pathway analysis. Changes in gene expression for WU-12 versus control were examined by RNA-seq for genes downstream of STAT3 in a heatmap (C) and boxplot (D), as well as MEK/MAPK pathway genes in a volcano plot (E), enrichment plot (F), and boxplot (G). P < 0.05 vs. vehicle control.
Metacore Pathway Map For Development Leptin Signaling Via Jak/Stat And Mitogen Activated Protein Kinase (Mapk) Cascades, supplied by GeneGo Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 90 stars, based on 1 article reviews
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mouse jak/stat signaling cdna pathway gene array system  (SuperArray Bioscience Corporation)
90
SuperArray Bioscience Corporation mouse jak/stat signaling cdna pathway gene array system
Figure 2. TYK2 inhibition leads to compensatory stimulation of the MAPK pathway in MPNST cells. A, JH-2–002 cells were treated with 40 mmol/L WU-12 or control for 48 hours, and gene expression was analyzed by <t>qPCR</t> array for JAK/STAT pathway–related genes. Log2 fold changes of significantly changed genes are graphed. B, JW23.3 cellswere treated with control or 40 mmol/LWU-12 or WU-76 for 48 hours. Global gene expressionwas determined byRNA-seq pathway analysis. Changes in gene expression for WU-12 versus control were examined by RNA-seq for genes downstream of STAT3 in a heatmap (C) and boxplot (D), as well as MEK/MAPK pathway genes in a volcano plot (E), enrichment plot (F), and boxplot (G). P < 0.05 vs. vehicle control.
Mouse Jak/Stat Signaling Cdna Pathway Gene Array System, supplied by SuperArray Bioscience Corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/jak+stat/mouse+jak+stat+signaling+cdna+pathway+gene+array+system/pm21165556-69-34-42
Average 90 stars, based on 1 article reviews
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jak/stat signaling pathway  (The Company of Biologists)
90
The Company of Biologists jak/stat signaling pathway
Figure 2. TYK2 inhibition leads to compensatory stimulation of the MAPK pathway in MPNST cells. A, JH-2–002 cells were treated with 40 mmol/L WU-12 or control for 48 hours, and gene expression was analyzed by <t>qPCR</t> array for JAK/STAT pathway–related genes. Log2 fold changes of significantly changed genes are graphed. B, JW23.3 cellswere treated with control or 40 mmol/LWU-12 or WU-76 for 48 hours. Global gene expressionwas determined byRNA-seq pathway analysis. Changes in gene expression for WU-12 versus control were examined by RNA-seq for genes downstream of STAT3 in a heatmap (C) and boxplot (D), as well as MEK/MAPK pathway genes in a volcano plot (E), enrichment plot (F), and boxplot (G). P < 0.05 vs. vehicle control.
Jak/Stat Signaling Pathway, supplied by The Company of Biologists, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/jak+stat/jak+stat+signaling+pathway/pm12441298-10-2-39
Average 90 stars, based on 1 article reviews
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Image Search Results


Fig. 1. Normalized TMPRSS2-HiBiT signal under treatment of compounds from (A) diversified building block library, (B) bioactive compound library, or (C) human endogenous metabolite library, at concentration of 10 μM and adjusted to corresponding ATP-Glo signal.

Journal: Biochemistry and biophysics reports

Article Title: NanoLuciferase technology-based detection of TMPRSS2 as attempt to develop anti-coronavirus agents.

doi: 10.1016/j.bbrep.2024.101783

Figure Lengend Snippet: Fig. 1. Normalized TMPRSS2-HiBiT signal under treatment of compounds from (A) diversified building block library, (B) bioactive compound library, or (C) human endogenous metabolite library, at concentration of 10 μM and adjusted to corresponding ATP-Glo signal.

Article Snippet: Diversified building block compound library, bioactive compound library and endogenous metabolite compound library were from TargetMol.

Techniques: Blocking Assay, Drug discovery, Concentration Assay

Figure 2. TYK2 inhibition leads to compensatory stimulation of the MAPK pathway in MPNST cells. A, JH-2–002 cells were treated with 40 mmol/L WU-12 or control for 48 hours, and gene expression was analyzed by qPCR array for JAK/STAT pathway–related genes. Log2 fold changes of significantly changed genes are graphed. B, JW23.3 cellswere treated with control or 40 mmol/LWU-12 or WU-76 for 48 hours. Global gene expressionwas determined byRNA-seq pathway analysis. Changes in gene expression for WU-12 versus control were examined by RNA-seq for genes downstream of STAT3 in a heatmap (C) and boxplot (D), as well as MEK/MAPK pathway genes in a volcano plot (E), enrichment plot (F), and boxplot (G). P < 0.05 vs. vehicle control.

Journal: Clinical Cancer Research

Article Title: MEK Inhibition Synergizes with TYK2 Inhibitors in NF1-Associated Malignant Peripheral Nerve Sheath Tumors

doi: 10.1158/1078-0432.ccr-22-3722

Figure Lengend Snippet: Figure 2. TYK2 inhibition leads to compensatory stimulation of the MAPK pathway in MPNST cells. A, JH-2–002 cells were treated with 40 mmol/L WU-12 or control for 48 hours, and gene expression was analyzed by qPCR array for JAK/STAT pathway–related genes. Log2 fold changes of significantly changed genes are graphed. B, JW23.3 cellswere treated with control or 40 mmol/LWU-12 or WU-76 for 48 hours. Global gene expressionwas determined byRNA-seq pathway analysis. Changes in gene expression for WU-12 versus control were examined by RNA-seq for genes downstream of STAT3 in a heatmap (C) and boxplot (D), as well as MEK/MAPK pathway genes in a volcano plot (E), enrichment plot (F), and boxplot (G). P < 0.05 vs. vehicle control.

Article Snippet: Phosphorylated protein levels were normalized to the respective total protein levels and expressed as a percent of control for each time point. qPCR pathway array The effect of WU-12 on gene expression of potential downstream targets known to be in the JAK–STAT pathway was assessed by a PrimerArray JAK–STAT Signaling Pathway (Human) qPCR array in 96-well plate format (Takara Bio).

Techniques: Inhibition, Control, Gene Expression, RNA Sequencing